Histamine, estrogen, and mast cells may be an overlooked link in perimenopause symptoms like migraines, hives, insomnia, and brain fog. In this educational guide, Michelle Pesce of Hello Palate explores the science behind histamine intolerance, hormonal shifts, and DAO enzyme activity—offering an informed, supportive pathway to help women navigate midlife with clarity, confidence, and provider-ready knowledge.

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